| Title |
Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension
|
|---|---|
| Published in |
Plant Foods for Human Nutrition, July 2013
|
| DOI | 10.1007/s11130-013-0368-7 |
| Pubmed ID | |
| Authors |
N. Mihailovic-Stanojevic, A. Belščak-Cvitanović, J. Grujić-Milanović, M. Ivanov, Dj. Jovović, D. Bugarski, Z. Miloradović |
| Abstract |
The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 ± 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43% with the IC50 value of 122.36 μg/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 6 | 10% |
| Researcher | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Other | 12 | 19% |
| Unknown | 15 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Medicine and Dentistry | 5 | 8% |
| Chemistry | 4 | 6% |
| Other | 11 | 17% |
| Unknown | 18 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2016.
All research outputs
#2,125,271
of 22,721,584 outputs
Outputs from Plant Foods for Human Nutrition
#94
of 701 outputs
Outputs of similar age
#19,223
of 194,403 outputs
Outputs of similar age from Plant Foods for Human Nutrition
#2
of 8 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 701 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,403 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.