↓ Skip to main content

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 1997
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

blogs
1 blog
policy
2 policy sources
twitter
18 X users
patent
4 patents
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
1186 Dimensions

Readers on

mendeley
340 Mendeley
citeulike
2 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 1997
DOI 10.1073/pnas.94.7.3290
Pubmed ID
Authors

Benjamin C. Blount, Matthew M. Mack, Carol M. Wehr, James T. MacGregor, Robert A. Hiatt, Gene Wang, Sunitha N. Wickramasinghe, Richard B. Everson, Bruce N. Ames

Abstract

Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely mechanism is the deficient methylation of dUMP to dTMP and subsequent incorporation of uracil into DNA by DNA polymerase. During repair of uracil in DNA, transient nicks are formed; two opposing nicks could lead to chromosome breaks. Both high DNA uracil levels and elevated micronucleus frequency (a measure of chromosome breaks) are reversed by folate administration. A significant proportion of the U.S. population has low folate levels, in the range associated with elevated uracil misincorporation and chromosome breaks. Such breaks could contribute to the increased risk of cancer and cognitive defects associated with folate deficiency in humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 340 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
United Kingdom 2 <1%
Italy 1 <1%
India 1 <1%
Colombia 1 <1%
Canada 1 <1%
Hungary 1 <1%
Russia 1 <1%
Mexico 1 <1%
Other 0 0%
Unknown 325 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 77 23%
Student > Master 46 14%
Researcher 42 12%
Student > Bachelor 42 12%
Student > Postgraduate 19 6%
Other 59 17%
Unknown 55 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 99 29%
Biochemistry, Genetics and Molecular Biology 68 20%
Medicine and Dentistry 57 17%
Chemistry 12 4%
Nursing and Health Professions 9 3%
Other 35 10%
Unknown 60 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2023.
All research outputs
#1,155,937
of 25,204,049 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#17,069
of 102,555 outputs
Outputs of similar age
#347
of 30,892 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#11
of 528 outputs
Altmetric has tracked 25,204,049 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 102,555 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 30,892 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 528 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.