Title |
Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
|
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Published in |
Trends in Biotechnology, September 2013
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DOI | 10.1016/j.tibtech.2013.06.005 |
Pubmed ID | |
Authors |
Susmita Bose, Gary Fielding, Solaiman Tarafder, Amit Bandyopadhyay |
Abstract |
General trends in synthetic bone grafting materials are shifting towards approaches that can illicit osteoinductive properties. Pharmacologics and biologics have been used in combination with calcium phosphate (CaP) ceramics, however, they have recently become the target of scrutiny over safety. The importance of trace elements in natural bone health is well documented. Ions, for example, lithium, zinc, magnesium, manganese, silicon, strontium, etc., have been shown to increase osteogenesis and neovascularization. Incorporation of dopants (trace metal ions) into CaPs can provide a platform for safe and efficient delivery in clinical applications where increased bone healing is favorable. This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | <1% |
Brazil | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Korea, Republic of | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 365 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 70 | 19% |
Researcher | 56 | 15% |
Student > Master | 54 | 15% |
Student > Bachelor | 34 | 9% |
Student > Doctoral Student | 20 | 5% |
Other | 52 | 14% |
Unknown | 86 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Materials Science | 79 | 21% |
Engineering | 51 | 14% |
Agricultural and Biological Sciences | 31 | 8% |
Medicine and Dentistry | 30 | 8% |
Biochemistry, Genetics and Molecular Biology | 22 | 6% |
Other | 49 | 13% |
Unknown | 110 | 30% |