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Attention Score in Context
| Title |
A Novel Translational Assay of Response Inhibition and Impulsivity: Effects of Prefrontal Cortex Lesions, Drugs Used in ADHD, and Serotonin 2C Receptor Antagonism
|
|---|---|
| Published in |
Neuropsychopharmacology, May 2013
|
| DOI | 10.1038/npp.2013.112 |
| Pubmed ID | |
| Authors |
Trevor Humby, Jessica B Eddy, Mark A Good, Amy C Reichelt, Lawrence S Wilkinson |
| Abstract |
Animal models are making an increasing contribution to our understanding of the psychology and brain mechanisms underlying behavioral inhibition and impulsivity. The aim here was to develop, for the first time, a mouse analog of the stop-signal reaction time task with high translational validity in order to be able to exploit this species in genetic and molecular investigations of impulsive behaviors. Cohorts of mice were trained to nose-poke to presentations of visual stimuli. Control of responding was manipulated by altering the onset of an auditory 'stop-signal' during the go response. The anticipated systematic changes in action cancellation were observed as stopping was made more difficult by placing the stop-signal closer to the execution of the action. Excitotoxic lesions of medial prefrontal cortex resulted in impaired stopping, while the clinically effective drugs methylphenidate and atomoxetine enhanced stopping abilities. The specific 5-HT2C receptor antagonist SB242084 also led to enhanced response control in this task. We conclude that stop-signal reaction time task performance can be successfully modeled in mice and is sensitive to prefrontal cortex dysfunction and drug treatments in a qualitatively similar manner to humans and previous rat models. Additionally, using this model we show novel and highly discrete effects of 5-HT2C receptor antagonism that suggest manipulation of 5-HT2C receptor function may be of use in correcting maladaptive impulsive behaviors and provide further evidence for dissociable contributions of serotonergic transmission to response control. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| Germany | 2 | 2% |
| Japan | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 86 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Researcher | 18 | 19% |
| Student > Bachelor | 13 | 14% |
| Student > Master | 8 | 9% |
| Professor > Associate Professor | 7 | 7% |
| Other | 15 | 16% |
| Unknown | 14 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 26 | 28% |
| Neuroscience | 20 | 21% |
| Agricultural and Biological Sciences | 14 | 15% |
| Medicine and Dentistry | 8 | 9% |
| Social Sciences | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 18 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2013.
All research outputs
#20,202,510
of 22,721,584 outputs
Outputs from Neuropsychopharmacology
#3,902
of 4,103 outputs
Outputs of similar age
#168,730
of 193,646 outputs
Outputs of similar age from Neuropsychopharmacology
#52
of 54 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.