Title |
γ-Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178
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Published in |
Phytochemistry, February 2017
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DOI | 10.1016/j.phytochem.2017.02.008 |
Pubmed ID | |
Authors |
Patima Phainuphong, Vatcharin Rukachaisirikul, Kwanruthai Tadpetch, Yaowapa Sukpondma, Saowanit Saithong, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj |
Abstract |
Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic acid, dihydropenicillic acid, 5,6-dihydro-6-hydroxypenicillic acid, 6-methoxy-5,6-dihydropenicillic acid, coculnol and (4R,5R)-4,5-dihydroxy-3-methoxy-5-methylcyclohex-2-en-1-one. Their structures were determined by spectroscopic evidence. For aspersclerotiorones A and B, the structures were confirmed by single-crystal X-ray diffraction crystallography. Penicillic acid displayed weak antibacterial activity against Staphylococcus aureus and Escherichia coli with equal MIC values of 128 μg/mL, and it was noncytotoxic towards African green monkey kidney fibroblast cells. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 13% |
Researcher | 3 | 10% |
Other | 2 | 6% |
Student > Master | 2 | 6% |
Unspecified | 1 | 3% |
Other | 3 | 10% |
Unknown | 16 | 52% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Chemistry | 2 | 6% |
Unspecified | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 10% |
Unknown | 20 | 65% |