| Title |
Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2012
|
| DOI | 10.1007/s00018-012-1187-y |
| Pubmed ID | |
| Authors |
Seyed Mehdi Jafarnejad, Gholamreza Safaee Ardekani, Mazyar Ghaffari, Gang Li |
| Abstract |
In addition to their critical roles in embryonic development, cell fate decision, and differentiation, members of Sox (Sry-related high-mobility group box) family of transcription factors including Sox4 have been implicated in various cancers. Multiple studies have revealed an increased expression along with specific oncogenic function of Sox4 in tumors, while others observed a reduced expression of Sox4 in different types of malignancies and suppression of tumor initiation or progression by this protein. More interestingly, the prognostic value of Sox4 is debated due to obvious differences between various reports as well as inconsistencies within specific studies. This review summarizes our current understanding of Sox4 expression pattern and its transcription-dependent, as well as transcription-independent, functions in tumor initiation or progression and its correlation with patient survival. We also discuss the existing discrepancies between different reports and their possible explanations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 5% |
| Brazil | 1 | 5% |
| Unknown | 19 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 33% |
| Student > Bachelor | 4 | 19% |
| Researcher | 3 | 14% |
| Professor > Associate Professor | 2 | 10% |
| Student > Master | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 38% |
| Biochemistry, Genetics and Molecular Biology | 6 | 29% |
| Medicine and Dentistry | 5 | 24% |
| Linguistics | 1 | 5% |
| Unknown | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2013.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
of 4,151 outputs
Outputs of similar age
#112,503
of 177,788 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#21
of 30 outputs
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