Daniel Polak, Kawin Setsompop, Stephen F. Cauley, Borjan A. Gagoski, Himanshu Bhat, Florian Maier, Peter Bachert, Lawrence L. Wald, Berkin Bilgic

To introduce a highly accelerated T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) acquisition that uses wave-controlled aliasing in parallel imaging (wave-CAIPI) encoding to retain high image quality. Significant acceleration of the MP-RAGE sequence is demonstrated using the wave-CAIPI technique. Here, sinusoidal waveforms are used to spread aliasing in all three directions to improve the g-factor. Combined with a rapid (2 s) coil sensitivity acquisition and data-driven trajectory calibration, we propose an online integrated acquisition-reconstruction pipeline for highly efficient MP-RAGE imaging. The 9-fold accelerated MP-RAGE acquisition can be performed in 71 s, with a maximum and average g-factor of gmax  = 1.27 and gavg  = 1.06 at 3T. Compared with the state-of-the-art method controlled aliasing in parallel imaging results in higher acceleration (2D-CAIPIRINHA), this is a factor of 4.6/1.4 improvement in gmax /gavg . In addition, we demonstrate a 57 s acquisition at 7T with 12-fold acceleration. This acquisition has a g-factor performance of gmax  = 1.15 and gavg  = 1.04. Wave encoding overcomes the g-factor noise amplification penalty and allows for an order of magnitude acceleration of MP-RAGE acquisitions. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.