| Title |
Experimental measles encephalitis in Lewis rats: dissemination of infected neuronal cell subtypes
|
|---|---|
| Published in |
Journal of NeuroVirology, August 2013
|
| DOI | 10.1007/s13365-013-0199-1 |
| Pubmed ID | |
| Authors |
Ulrike Jehmlich, Jennifer Ritzer, Jens Grosche, Wolfgang Härtig, Uwe G. Liebert |
| Abstract |
Acute measles may lead in rare instances to the chronic progressive central nervous system disease process subacute sclerosing panencephalitis (SSPE). SSPE results from a persistent measles virus (MV) infection with incomplete virus replication involving the entire human brain. The experimental encephalitis model in Lewis rats was used to define affected cell populations after infection with the neurotropic MV strain CAM/RB. Distribution patterns of MV were analysed by appropriate cell markers in the brain sections of infected animals employing multiple immunofluorescence labelling and confocal laser scanning microscopy. MV was detected in neurones but not in astrocytes, oligodendrocytes, microglia, and endothelial cells. GABAergic and glutamatergic neurons displayed MV antigen whereas cholinergic and catecholaminergic neurons appeared devoid of MV immunoreactivity. Mapping of the rat brain has revealed MV-infected neurones predominantly in motor, somatosensory, auditory, and visual cortices as well as in the basal ganglia and thalamic nuclei of infected rats. The results indicate that MV apparently disseminates via GABAergic and glutaminergic neurones and their processes. The tightly restricted viral distribution pattern is consistent with both inefficient immune clearance from infected neurones and with the observed disease symptoms. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 28% |
| Student > Bachelor | 2 | 11% |
| Researcher | 2 | 11% |
| Professor | 2 | 11% |
| Student > Doctoral Student | 1 | 6% |
| Other | 3 | 17% |
| Unknown | 3 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 22% |
| Veterinary Science and Veterinary Medicine | 3 | 17% |
| Neuroscience | 2 | 11% |
| Agricultural and Biological Sciences | 2 | 11% |
| Nursing and Health Professions | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from Journal of NeuroVirology
#653
of 925 outputs
Outputs of similar age
#149,662
of 200,083 outputs
Outputs of similar age from Journal of NeuroVirology
#11
of 22 outputs
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