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Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

Overview of attention for article published in American Journal of Gastroenterology, September 2013
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1 X user
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Citations

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Title
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
Published in
American Journal of Gastroenterology, September 2013
DOI 10.1038/ajg.2013.292
Pubmed ID
Authors

Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, Ian PM Tomlinson, Oliver M Sieber

Abstract

Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and BRAF, that have been associated with prognosis. It is not known which of MSI, CIN, and the specific gene mutations are primary predictors of survival.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ukraine 1 1%
Belgium 1 1%
South Africa 1 1%
Unknown 97 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 21%
Researcher 21 21%
Student > Master 11 11%
Other 9 9%
Lecturer > Senior Lecturer 5 5%
Other 14 14%
Unknown 19 19%
Readers by discipline Count As %
Medicine and Dentistry 34 34%
Biochemistry, Genetics and Molecular Biology 18 18%
Agricultural and Biological Sciences 17 17%
Computer Science 3 3%
Nursing and Health Professions 2 2%
Other 6 6%
Unknown 20 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2013.
All research outputs
#16,681,672
of 25,837,817 outputs
Outputs from American Journal of Gastroenterology
#4,745
of 5,899 outputs
Outputs of similar age
#125,474
of 217,541 outputs
Outputs of similar age from American Journal of Gastroenterology
#31
of 38 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,899 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,541 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.