Title |
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
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Published in |
American Journal of Gastroenterology, September 2013
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DOI | 10.1038/ajg.2013.292 |
Pubmed ID | |
Authors |
Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, Ian PM Tomlinson, Oliver M Sieber |
Abstract |
Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and BRAF, that have been associated with prognosis. It is not known which of MSI, CIN, and the specific gene mutations are primary predictors of survival. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ukraine | 1 | 1% |
Belgium | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 97 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 21% |
Researcher | 21 | 21% |
Student > Master | 11 | 11% |
Other | 9 | 9% |
Lecturer > Senior Lecturer | 5 | 5% |
Other | 14 | 14% |
Unknown | 19 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 34 | 34% |
Biochemistry, Genetics and Molecular Biology | 18 | 18% |
Agricultural and Biological Sciences | 17 | 17% |
Computer Science | 3 | 3% |
Nursing and Health Professions | 2 | 2% |
Other | 6 | 6% |
Unknown | 20 | 20% |