Title |
Therapeutic Potential of Regulatory T cells in Autoimmune Disorders
|
---|---|
Published in |
BioDrugs, April 2013
|
DOI | 10.1007/s40259-013-0026-5 |
Pubmed ID | |
Authors |
Johannes Fessler, Anja Felber, Christina Duftner, Christian Dejaco |
Abstract |
Regulatory T cells (Tregs) play a dominant role in the regulation of immune responses. Quantitative and/or qualitative abnormalities of Tregs were observed in patients with autoimmune diseases and therapeutic interventions focusing Tregs are an attractive new target with the potential to cure these disorders. Biological agents approved for treatment of inflammatory rheumatic diseases transiently influence Treg prevalences and function and experimental therapies including novel biological agents, gene therapy, activation and ex vivo expansion of purified Tregs as well as substances influencing tolerogenic dendritic cells will be developed for selective Treg therapy. Although many of these interventions are effective in vitro, in animal models as well as in early clinical trials, significant concerns exist regarding the stability of Treg modifications as well as the long-term safety of Treg-based therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 28% |
Student > Master | 7 | 22% |
Researcher | 6 | 19% |
Student > Bachelor | 3 | 9% |
Professor > Associate Professor | 2 | 6% |
Other | 3 | 9% |
Unknown | 2 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 34% |
Immunology and Microbiology | 8 | 25% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Medicine and Dentistry | 3 | 9% |
Nursing and Health Professions | 1 | 3% |
Other | 1 | 3% |
Unknown | 4 | 13% |