| Title |
Anticholinergic drug use and risk for dementia: target for dementia prevention
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, October 2010
|
| DOI | 10.1007/s00406-010-0156-4 |
| Pubmed ID | |
| Authors |
Frank Jessen, Hanna Kaduszkiewicz, Moritz Daerr, Horst Bickel, Michael Pentzek, Steffi Riedel-Heller, Michael Wagner, Siegfried Weyerer, Birgitt Wiese, Hendrik van den Bussche, Karl Broich, Wolfgang Maier |
| Abstract |
An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 90 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 15% |
| Student > Master | 13 | 14% |
| Other | 11 | 12% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Doctoral Student | 7 | 8% |
| Other | 20 | 22% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 29% |
| Psychology | 10 | 11% |
| Agricultural and Biological Sciences | 6 | 7% |
| Neuroscience | 5 | 5% |
| Social Sciences | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 25 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2019.
All research outputs
#1,973,783
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#105
of 1,243 outputs
Outputs of similar age
#7,321
of 101,525 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#2
of 10 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.