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Mendeley readers
Attention Score in Context
| Title |
Larger temporal volume in elderly with high versus low beta-amyloid deposition
|
|---|---|
| Published in |
Brain, August 2010
|
| DOI | 10.1093/brain/awq187 |
| Pubmed ID | |
| Authors |
Gaël Chételat, Victor L. Villemagne, Kerryn E. Pike, Jean-Claude Baron, Pierrick Bourgeat, Gareth Jones, Noel G. Faux, Kathryn A. Ellis, Olivier Salvado, Cassandra Szoeke, Ralph N. Martins, David Ames, Colin L. Masters, Christopher C. Rowe |
| Abstract |
β-Amyloid deposition is one of the main hallmarks of Alzheimer's disease thought to eventually cause neuronal death. Post-mortem and neuroimaging studies have consistently reported cases with documented normal cognition despite high β-amyloid burden. It is of great interest to understand what differentiates these particular subjects from those without β-amyloid deposition or with both β-amyloid deposition and cognitive deficits, i.e. what allows these subjects to resist the damage of the pathological lesions. [¹¹C]Pittsburgh compound B positron emission tomography and magnetic resonance brain scans were obtained in 149 participants including healthy controls and patients with subjective cognitive impairment, mild cognitive impairment and Alzheimer's disease. Magnetic resonance data were compared between high versus low-[11C]Pittsburgh compound B cases, and between high-[¹¹C]Pittsburgh compound B cases with versus those without cognitive deficits. Larger temporal (including hippocampal) grey matter volume, associated with better episodic memory performance, was found in high- versus low-[¹¹C]Pittsburgh compound B healthy controls. The same finding was obtained using different [¹¹C]Pittsburgh compound B thresholds, correcting [¹¹C]Pittsburgh compound B data for partial averaging, using age, education, Mini-Mental State Examination, apolipoprotein E4 and sex-matched subsamples, and using manual hippocampal delineation instead of voxel-based analysis. By contrast, in participants with subjective cognitive impairment, significant grey matter atrophy was found in high-[¹¹C]Pittsburgh compound B cases compared to low-[¹¹C]Pittsburgh compound B cases, as well as in high-[¹¹C]Pittsburgh compound B cases with subjective cognitive impairment, mild cognitive impairment and Alzheimer's disease compared to high-[¹¹C]Pittsburgh compound B healthy controls. Larger grey matter volume in high-[¹¹C]Pittsburgh compound B healthy controls may reflect either a tissue reactive response to β-amyloid or a combination of higher 'brain reserve' and under-representation of subjects with standard/low temporal volume in the high-[¹¹C]Pittsburgh compound B healthy controls. Our complementary analyses tend to support the latter hypotheses. Overall, our findings suggest that the deleterious effects of β-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume. |
Mendeley readers
The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 239 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 23% |
| Researcher | 37 | 15% |
| Student > Master | 34 | 14% |
| Student > Bachelor | 18 | 7% |
| Student > Doctoral Student | 17 | 7% |
| Other | 38 | 16% |
| Unknown | 44 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 49 | 20% |
| Psychology | 48 | 20% |
| Neuroscience | 37 | 15% |
| Agricultural and Biological Sciences | 17 | 7% |
| Social Sciences | 8 | 3% |
| Other | 33 | 13% |
| Unknown | 53 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2023.
All research outputs
#2,655,546
of 25,373,627 outputs
Outputs from Brain
#2,707
of 7,625 outputs
Outputs of similar age
#9,895
of 103,388 outputs
Outputs of similar age from Brain
#13
of 77 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,625 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,388 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.