| Title |
Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial
|
|---|---|
| Published in |
Cancer Immunology, Immunotherapy, April 2013
|
| DOI | 10.1007/s00262-013-1414-x |
| Pubmed ID | |
| Authors |
Christoph Domschke, Yingzi Ge, Isa Bernhardt, Sarah Schott, Sophia Keim, Simone Juenger, Mariana Bucur, Luisa Mayer, Maria Blumenstein, Joachim Rom, Joerg Heil, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Florian Schuetz |
| Abstract |
The bone marrow (BM) of breast cancer patients harbors tumor-reactive memory T cells (TCs) with therapeutic potential. We recently described the immunologic effects of adoptive transfer of ex vivo restimulated tumor-reactive memory TCs from the BM of 12 metastasized breast cancer patients in a clinical phase-I study. In this trial, adoptive T cell transfer resulted in the occurrence of circulating tumor antigen-reactive type-1 TCs. We here describe the long-term clinical outcome and its correlation with tumor-specific cellular immune response in 16 metastasized breast cancer patients, including 12 included in the original study. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 22% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 7 | 14% |
| Professor > Associate Professor | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 10 | 20% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 30% |
| Medicine and Dentistry | 13 | 26% |
| Immunology and Microbiology | 7 | 14% |
| Psychology | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 7 | 14% |