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Mendeley readers
Attention Score in Context
| Title |
Readthrough of dystrophin stop codon mutations induced by aminoglycosides
|
|---|---|
| Published in |
Annals of Neurology, January 2004
|
| DOI | 10.1002/ana.20052 |
| Pubmed ID | |
| Authors |
Michael T. Howard, Christine B. Anderson, Uwe Fass, Shikha Khatri, Raymond F. Gesteland, John F. Atkins, Kevin M. Flanigan |
| Abstract |
We report the translational readthrough levels induced by the aminoglycosides gentamicin, amikacin, tobramycin, and paromomycin for eight premature stop codon mutations identified in Duchenne's and Becker's muscular dystrophy patients. In a transient transfection reporter assay, aminoglycoside treatment results show that one stop codon mutation is suppressed significantly better (up to 10% stop codon readthrough) than the others; five show lower but statistically significant suppression (< 2% stop codon readthrough); and two appear refractory to aminoglycoside treatment. Readthrough levels do not substantially vary between different sources of gentamicin, and, for this set of mutations, the efficiency of termination at the premature stop codon mutation does not appear to correlate with disease severity. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Israel | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 77 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 25% |
| Researcher | 14 | 17% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 8 | 10% |
| Professor | 7 | 9% |
| Other | 13 | 16% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 42% |
| Biochemistry, Genetics and Molecular Biology | 14 | 17% |
| Chemistry | 9 | 11% |
| Medicine and Dentistry | 6 | 7% |
| Social Sciences | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 10 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2024.
All research outputs
#3,273,528
of 24,627,841 outputs
Outputs from Annals of Neurology
#1,536
of 5,556 outputs
Outputs of similar age
#8,707
of 139,818 outputs
Outputs of similar age from Annals of Neurology
#17
of 104 outputs
Altmetric has tracked 24,627,841 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.