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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
|
|---|---|
| Published in |
PLoS Genetics, September 2013
|
| DOI | 10.1371/journal.pgen.1003796 |
| Pubmed ID | |
| Authors |
Conall M. O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M. Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A. Catharina Brockhaus, Marcus E. Kleber, Anubha Mahajan, Florian D. Ernst, Vilmundur Gudnason, Lenore J. Launer, Aurelien Mace, Eric Boerwinckle, Dan E. Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J. Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S. Siscovick, Bruce M. Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F. Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M. Brown, Karol Estrada, Jingzhong Ding, Tamara B. Harris, Stefania Bandinelli, Dena Hernandez, Andrew B. Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M. Starr, John C. Chambers, Bernhard O. Boehm, Bernhard R. Winkelmann, Jie Huang, Federico Murgia, Sarah H. Wild, Harry Campbell, Andrew P. Morris, Oscar H. Franco, Albert Hofman, Andre G. Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So–Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, Patricia B. Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D. Spector, Albert V. Smith, Igor Rudan, James F. Wilson, Ozren Polasek, Ian J. Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S. Kooner, Jacqueline C. M. Witteman, Matthias Nauck, W. H. Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S. Fox, Murielle Bochud |
| Abstract |
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤ 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 33% |
| India | 1 | 33% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 144 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 22% |
| Student > Ph. D. Student | 30 | 20% |
| Professor | 10 | 7% |
| Student > Bachelor | 10 | 7% |
| Professor > Associate Professor | 9 | 6% |
| Other | 26 | 18% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 27% |
| Biochemistry, Genetics and Molecular Biology | 31 | 21% |
| Agricultural and Biological Sciences | 21 | 14% |
| Mathematics | 3 | 2% |
| Chemistry | 3 | 2% |
| Other | 14 | 10% |
| Unknown | 35 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2023.
All research outputs
#14,817,495
of 25,707,225 outputs
Outputs from PLoS Genetics
#6,021
of 8,997 outputs
Outputs of similar age
#111,413
of 214,211 outputs
Outputs of similar age from PLoS Genetics
#101
of 208 outputs
Altmetric has tracked 25,707,225 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,997 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,211 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 208 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.