Title |
Detection of human leptospirosis as a cause of acute fever by capture ELISA using a Leptospira interrogansserovar Copenhageni (M20) derived antigen
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Published in |
BMC Infectious Diseases, September 2013
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DOI | 10.1186/1471-2334-13-438 |
Pubmed ID | |
Authors |
Enrique Canal, Simon Pollett, Kristen Heitzinger, Michael Gregory, Matthew Kasper, Eric Halsey, Yocelinda Meza, Kalina Campos, Juan Perez, Rina Meza, Maruja Bernal, Alfredo Guillen, Tadeusz J Kochel, Benjamin Espinosa, Eric R Hall, Ryan C Maves |
Abstract |
Leptospirosis is a potentially lethal zoonosis mainly affecting low-resource tropical countries, including Peru and its neighbouring countries. Timely diagnosis of leptospirosis is critical but may be challenging in the regions where it is most prevalent. The serodiagnostic gold standard microagglutination test (MAT) may be technically prohibitive. Our objective in this study was to assess the sensitivity, specificity, and predictive value of an IgM antibody capture enzyme-linked immunoassay (MAC-ELISA) derived from the M20 strain of Leptospira interrogans serovar Copenhageni (M20) by comparison to MAT, which was used as the gold standard method of diagnosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 3% |
Colombia | 1 | 2% |
Sri Lanka | 1 | 2% |
Unknown | 60 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 17% |
Student > Master | 8 | 13% |
Student > Bachelor | 8 | 13% |
Student > Ph. D. Student | 7 | 11% |
Student > Doctoral Student | 4 | 6% |
Other | 10 | 16% |
Unknown | 16 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 19% |
Agricultural and Biological Sciences | 8 | 13% |
Veterinary Science and Veterinary Medicine | 7 | 11% |
Immunology and Microbiology | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Other | 10 | 16% |
Unknown | 18 | 28% |