| Title |
Neuroinflammation in Neurodegenerative Disorders—a Review
|
|---|---|
| Published in |
Current Neurology and Neuroscience Reports, March 2017
|
| DOI | 10.1007/s11910-017-0733-2 |
| Pubmed ID | |
| Authors |
Martin Schain, William Charles Kreisl |
| Abstract |
The potential for positron emission tomography (PET) to detect neuroinflammation in vivo has sparked a remarkable interest in various disciplines of neuroscience. Early PET radioligands, such as [(11)C]PK(R)-11195 for the 18-kDa translocator protein (TSPO) and [(11)C]L-deprenyl for monoamine oxidase B, have been used in studies designed to clarify the role of neuroinflammation in a variety of psychiatric and neurological disorders. Recent years have witnessed the development of several second-generation PET radioligands for TSPO and radioligands to measure endogenous targets that are active in various stages of the inflammatory cascade, such as cyclooxygenase and arachidonic acid. Here, we discuss some of the biomarkers for neuroinflammation that are available for quantification with PET, as well as recent findings from studies where neuroinflammation has been assessed in neurodegenerative disorders. In addition, we highlight the challenges to accurate interpretation of PET studies of neuroinflammation. |
Mendeley readers
The data shown below were compiled from readership statistics for 362 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 361 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 52 | 14% |
| Student > Ph. D. Student | 51 | 14% |
| Researcher | 46 | 13% |
| Student > Master | 43 | 12% |
| Student > Doctoral Student | 16 | 4% |
| Other | 62 | 17% |
| Unknown | 92 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 69 | 19% |
| Biochemistry, Genetics and Molecular Biology | 54 | 15% |
| Medicine and Dentistry | 41 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 5% |
| Agricultural and Biological Sciences | 16 | 4% |
| Other | 38 | 10% |
| Unknown | 127 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2017.
All research outputs
#4,210,168
of 22,959,818 outputs
Outputs from Current Neurology and Neuroscience Reports
#234
of 919 outputs
Outputs of similar age
#75,681
of 307,832 outputs
Outputs of similar age from Current Neurology and Neuroscience Reports
#15
of 36 outputs
Altmetric has tracked 22,959,818 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 919 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.