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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
|
|---|---|
| Published in |
Pharmacology, Biochemistry & Behavior, September 2013
|
| DOI | 10.1016/j.pbb.2013.08.013 |
| Pubmed ID | |
| Authors |
Daniel J. Liput, Dana C. Hammell, Audra L. Stinchcomb, Kimberly Nixon |
| Abstract |
Excessive alcohol consumption, characteristic of alcohol use disorders, results in neurodegeneration and behavioral and cognitive impairments that are hypothesized to contribute to the chronic and relapsing nature of alcoholism. Therefore, the current study aimed to advance the preclinical development of transdermal delivery of cannabidiol (CBD) for the treatment of alcohol-induced neurodegeneration. In Experiment 1, 1.0%, 2.5% and 5.0% CBD gels were evaluated for neuroprotection. The 5.0% CBD gel resulted in a 48.8% reduction in neurodegeneration in the entorhinal cortex assessed by Fluoro-Jade B (FJB), which trended to statistical significance (p=0.069). Treatment with the 5.0% CBD gel resulted in day 3 CBD plasma concentrations of ~100.0 ng/mL so this level was used as a target concentration for development of an optimized gel formulation. Experiment 2 tested a next generation 2.5% CBD gel formulation, which was compared to CBD administration by intraperitoneal injection (IP; 40.0 mg/kg/day). This experiment found similar magnitudes of neuroprotection following both routes of administration; transdermal CBD decreased FJB+ cells in the entorhinal cortex by 56.1% (p<0.05), while IP CBD resulted in a 50.6% (p<0.05) reduction in FJB+ cells. These results demonstrate the feasibility of using CBD transdermal delivery systems for the treatment of alcohol-induced neurodegeneration. |
X Demographics
The data shown below were collected from the profiles of 193 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 54 | 28% |
| United States | 44 | 23% |
| Netherlands | 3 | 2% |
| Australia | 2 | 1% |
| Spain | 1 | <1% |
| Côte d'Ivoire | 1 | <1% |
| Nepal | 1 | <1% |
| India | 1 | <1% |
| Korea, Democratic People's Republic of | 1 | <1% |
| Other | 7 | 4% |
| Unknown | 78 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 180 | 93% |
| Practitioners (doctors, other healthcare professionals) | 9 | 5% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
| Scientists | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 13% |
| Student > Bachelor | 14 | 12% |
| Researcher | 13 | 11% |
| Student > Master | 13 | 11% |
| Other | 9 | 8% |
| Other | 23 | 19% |
| Unknown | 32 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 11% |
| Neuroscience | 13 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 8% |
| Medicine and Dentistry | 9 | 8% |
| Psychology | 9 | 8% |
| Other | 32 | 27% |
| Unknown | 33 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 222. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2022.
All research outputs
#177,292
of 25,844,815 outputs
Outputs from Pharmacology, Biochemistry & Behavior
#9
of 3,173 outputs
Outputs of similar age
#1,148
of 210,079 outputs
Outputs of similar age from Pharmacology, Biochemistry & Behavior
#1
of 21 outputs
Altmetric has tracked 25,844,815 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,173 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,079 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.