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Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells

Overview of attention for article published in Biochimica et Biophysica Acta (BBA), April 2013
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

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1 Facebook page
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2 Wikipedia pages

Citations

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133 Dimensions

Readers on

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93 Mendeley
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Title
Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells
Published in
Biochimica et Biophysica Acta (BBA), April 2013
DOI 10.1016/j.bbamcr.2013.04.011
Pubmed ID
Authors

Jaganmohan Reddy Jangamreddy, Saeid Ghavami, Jerzy Grabarek, Gunnar Kratz, Emilia Wiechec, Bengt-Arne Fredriksson, Rama Krishna Rao Pariti, Artur Cieślar-Pobuda, Soumya Panigrahi, Marek J. Łos

Abstract

The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies reported that Ca(2+), cytochrome c, and caspase activation play a role in Salinomycin-induced cytotoxicity. Furthermore, Salinomycin may target Wnt/β-catenin signaling pathway to promote differentiation and thus elimination of cancer stem cells. In this study, we show a massive autophagic response to Salinomycin (substantially stronger than to commonly used autophagic inducer Rapamycin) in prostrate-, breast cancer cells, and to lesser degree in human normal dermal fibroblasts. Interestingly, autophagy induced by Salinomycin is a cell protective mechanism in all tested cancer cell lines. Furthermore, Salinomycin induces mitophagy, mitoptosis and increased mitochondrial membrane potential (∆Ψ) in a subpopulation of cells. Salinomycin strongly, and in time-dependent manner decreases cellular ATP level. Contrastingly, human normal dermal fibroblasts treated with Salinomycin show some initial decrease in mitochondrial mass, however they are largely resistant to Salinomycin-triggered ATP-depletion. Our data provide new insight into the molecular mechanism of preferential toxicity of Salinomycin towards cancer cells, and suggest possible clinical application of Salinomycin in combination with autophagy inhibitors (i.e. clinically-used Chloroquine). Furthermore, we discuss preferential Salinomycins toxicity in the context of Warburg effect.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Croatia 1 1%
United States 1 1%
Unknown 91 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 24%
Student > Master 12 13%
Researcher 10 11%
Student > Bachelor 9 10%
Student > Doctoral Student 8 9%
Other 19 20%
Unknown 13 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 20%
Agricultural and Biological Sciences 16 17%
Medicine and Dentistry 14 15%
Pharmacology, Toxicology and Pharmaceutical Science 11 12%
Chemistry 5 5%
Other 12 13%
Unknown 16 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2020.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Biochimica et Biophysica Acta (BBA)
#5,904
of 19,218 outputs
Outputs of similar age
#67,627
of 204,179 outputs
Outputs of similar age from Biochimica et Biophysica Acta (BBA)
#79
of 210 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 19,218 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,179 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.