Title |
The Use of Hypertonic Saline for Treating Intracranial Hypertension After Traumatic Brain Injury
|
---|---|
Published in |
Anesthesia and analgesia, June 2006
|
DOI | 10.1213/01.ane.0000217208.51017.56 |
Pubmed ID | |
Authors |
Hayden White, David Cook, Bala Venkatesh |
Abstract |
The past decade has witnessed a resurgence of interest in the use of hypertonic saline for low-volume resuscitation after trauma. Preliminary studies suggested that benefits are limited to a subgroup of trauma patients with brain injury, but a recent study of prehospital administration of hypertonic saline to patients with traumatic brain injury failed to confirm a benefit. Animal and human studies have demonstrated that hypertonic saline has clinically desirable physiological effects on cerebral blood flow, intracranial pressure, and inflammatory responses in models of neurotrauma. There are few clinical studies in traumatic brain injury with patient survival as an end point. In this review, we examined the experimental and clinical knowledge of hypertonic saline as an osmotherapeutic agent in neurotrauma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Mexico | 1 | <1% |
Colombia | 1 | <1% |
Denmark | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 172 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 26 | 14% |
Student > Postgraduate | 23 | 13% |
Researcher | 21 | 12% |
Professor > Associate Professor | 15 | 8% |
Student > Master | 14 | 8% |
Other | 55 | 31% |
Unknown | 26 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 119 | 66% |
Neuroscience | 6 | 3% |
Nursing and Health Professions | 6 | 3% |
Agricultural and Biological Sciences | 4 | 2% |
Biochemistry, Genetics and Molecular Biology | 3 | 2% |
Other | 10 | 6% |
Unknown | 32 | 18% |