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Synergistic influence of polyoxometalate surface corona towards enhancing the antibacterial performance of tyrosine-capped Ag nanoparticles

Overview of attention for article published in Nanoscale, January 2014
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Title
Synergistic influence of polyoxometalate surface corona towards enhancing the antibacterial performance of tyrosine-capped Ag nanoparticles
Published in
Nanoscale, January 2014
DOI 10.1039/c3nr03806h
Pubmed ID
Authors

Hemant K. Daima, P. R. Selvakannan, Ahmad E. Kandjani, Ravi Shukla, Suresh K. Bhargava, Vipul Bansal

Abstract

We illustrate a new strategy to improve the antibacterial potential of silver nanoparticles (AgNPs) by their surface modification with the surface corona of biologically active polyoxometalates (POMs). The stable POM surface corona was achieved by utilising zwitterionic tyrosine amino acid as a pH-switchable reducing and capping agent of AgNPs. The general applicability of this approach was demonstrated by developing surface coronas of phosphotungstic acid (PTA) and phosphomolybdic acid (PMA) around AgNPs. Our investigations on Gram negative bacterium Escherichia coli demonstrate that in conjugation with AgNPs, the surface corona of POMs enhances the physical damage to the bacterial cells due to synergistic antibacterial action of AgNPs and POMs, and the ability of tyrosine-reduced AgNPs (AgNPs(Y)) to act as an excellent carrier and stabiliser for the POMs. The further extension of this study towards Gram positive bacterium Staphylococcus albus showed a similar toxicity pattern, whereas these nanomaterials were found to be biocompatible for PC3 epithelial mammalian cells, suggesting the potential of these materials towards specific antimicrobial targeting for topical wound healing applications. The outcomes of this work show that facile tailorability of nanostructured surfaces may play a considerable role in controlling the biological activities of different nanomaterials.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Australia 1 1%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 21%
Researcher 13 15%
Student > Master 9 10%
Student > Bachelor 8 9%
Student > Doctoral Student 5 6%
Other 16 19%
Unknown 17 20%
Readers by discipline Count As %
Chemistry 20 23%
Agricultural and Biological Sciences 13 15%
Materials Science 7 8%
Engineering 5 6%
Chemical Engineering 4 5%
Other 11 13%
Unknown 26 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2013.
All research outputs
#18,348,542
of 22,723,682 outputs
Outputs from Nanoscale
#5,839
of 9,183 outputs
Outputs of similar age
#229,256
of 305,150 outputs
Outputs of similar age from Nanoscale
#347
of 447 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,183 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,150 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 447 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.