Title |
A review of the relationship between tooth loss, periodontal disease, and cancer
|
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Published in |
Cancer Causes & Control, May 2008
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DOI | 10.1007/s10552-008-9163-4 |
Pubmed ID | |
Authors |
Mara S. Meyer, Kaumudi Joshipura, Edward Giovannucci, Dominique S. Michaud |
Abstract |
Recent studies have investigated the association between periodontal disease, tooth loss, and several systemic diseases including cancer, cardiovascular disease, and preterm birth. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between oral health and cancer has been examined for a number of specific cancer sites. Several studies have reported associations between periodontal disease or tooth loss and risk of oral, upper gastrointestinal, lung, and pancreatic cancer in different populations. In a number of studies, these associations persisted after adjustment for major risk factors, including cigarette smoking and socioeconomic status. This review provides a summary of these findings, discusses possible biological mechanisms involved, and raises methodological issues related to studying these relationships. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Australia | 2 | <1% |
Brazil | 1 | <1% |
Unknown | 236 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 14% |
Student > Bachelor | 34 | 14% |
Student > Master | 31 | 13% |
Researcher | 26 | 11% |
Other | 15 | 6% |
Other | 48 | 20% |
Unknown | 53 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 114 | 47% |
Biochemistry, Genetics and Molecular Biology | 17 | 7% |
Agricultural and Biological Sciences | 12 | 5% |
Social Sciences | 5 | 2% |
Nursing and Health Professions | 4 | 2% |
Other | 32 | 13% |
Unknown | 57 | 24% |