| Title |
Control of bacterial chromosome replication by non-coding regions outside the origin
|
|---|---|
| Published in |
Current Genetics, December 2016
|
| DOI | 10.1007/s00294-016-0671-6 |
| Pubmed ID | |
| Authors |
Jakob Frimodt-Møller, Godefroid Charbon, Anders Løbner-Olesen |
| Abstract |
Chromosome replication in Eubacteria is initiated by initiator protein(s) binding to specific sites within the replication origin, oriC. Recently, initiator protein binding to chromosomal regions outside the origin has attracted renewed attention; as such binding sites contribute to control the frequency of initiations. These outside-oriC binding sites function in several different ways: by steric hindrances of replication fork assembly, by titration of initiator proteins away from the origin, by performing a chaperone-like activity for inactivation- or activation of initiator proteins or by mediating crosstalk between chromosomes. Here, we discuss initiator binding to outside-oriC sites in a broad range of different taxonomic groups, to highlight the significance of such regions for regulation of bacterial chromosome replication. For Escherichia coli, it was recently shown that the genomic positions of regulatory elements are important for bacterial fitness, which, as we discuss, could be true for several other organisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 29% |
| Student > Ph. D. Student | 5 | 29% |
| Lecturer > Senior Lecturer | 2 | 12% |
| Student > Master | 2 | 12% |
| Lecturer | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 1 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 53% |
| Agricultural and Biological Sciences | 5 | 29% |
| Immunology and Microbiology | 1 | 6% |
| Physics and Astronomy | 1 | 6% |
| Unknown | 1 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2017.
All research outputs
#8,190,375
of 24,546,092 outputs
Outputs from Current Genetics
#344
of 1,218 outputs
Outputs of similar age
#143,484
of 429,175 outputs
Outputs of similar age from Current Genetics
#4
of 13 outputs
Altmetric has tracked 24,546,092 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,218 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.