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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Inhibiting the HIV Integration Process: Past, Present, and the Future
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, September 2013
|
| DOI | 10.1021/jm400674a |
| Pubmed ID | |
| Authors |
Roberto Di Santo |
| Abstract |
HIV integrase (IN) catalyzes the insertion into the genome of the infected human cell of viral DNA produced by the retrotranscription process. The discovery of raltegravir validated the existence of the IN, which is a new target in the field of anti-HIV drug research. The mechanism of catalysis of IN is depicted, and the characteristics of the inhibitors of the catalytic site of this viral enzyme are reported. The role played by the resistance is elucidated, as well as the possibility of bypassing this problem. New approaches to block the integration process are depicted as future perspectives, such as development of allosteric IN inhibitors, dual inhibitors targeting both IN and other enzymes, inhibitors of enzymes that activate IN, activators of IN activity, as well as a gene therapy approach. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Belgium | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 75% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Colombia | 1 | 1% |
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| United Kingdom | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 89 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Master | 15 | 16% |
| Student > Bachelor | 13 | 14% |
| Researcher | 12 | 13% |
| Student > Doctoral Student | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 22 | 23% |
| Medicine and Dentistry | 13 | 14% |
| Agricultural and Biological Sciences | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Immunology and Microbiology | 10 | 11% |
| Other | 7 | 7% |
| Unknown | 19 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2019.
All research outputs
#2,065,569
of 22,723,682 outputs
Outputs from Journal of Medicinal Chemistry
#1,293
of 22,029 outputs
Outputs of similar age
#19,697
of 203,246 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#8
of 154 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,029 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,246 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.