You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing
|
|---|---|
| Published in |
Neuropsychopharmacology, March 2017
|
| DOI | 10.1038/npp.2017.59 |
| Pubmed ID | |
| Authors |
Carolin Wackerhagen, Torsten Wüstenberg, Sebastian Mohnke, Susanne Erk, Ilya M Veer, Johann D Kruschwitz, Maria Garbusow, Lydia Romund, Kristina Otto, Janina I Schweiger, Heike Tost, Andreas Heinz, Andreas Meyer-Lindenberg, Henrik Walter, Nina Romanczuk-Seiferth |
| Abstract |
Imbalances in cortico-limbic activity and functional connectivity (FC) supposedly underlie biased emotional processing and present putative intermediate phenotypes (IPs) for major depressive disorder (MDD). To prove the validity of these IPs, we assessed them in familial risk during implicit emotional processing. To provide comparable data to previous studies and additionally elucidate the implications of altered functional connectivity, amygdala FC was assessed across and between task conditions. In 70 healthy first-degree relatives of MDD patients and 70 controls, brain activity and seed-based amygdala FC were assessed during an angry and fearful faces matching task for fMRI. Comparisons of amygdala FC across and between conditions were performed using generalized psychophysiological interactions. Associations with self-reported negative affect (NA) were explored post-hoc. Groups did not differ in brain activation. In relatives, amygdala FC across conditions was decreased with superior and medial frontal gyrus (SFG, MFG) and increased with pgACC and subgenual ACC. NA was inversely correlated with amygdala FC with MFG, pgACC and their interaction in relatives. Relatives showed aberrant condition-dependent modulations of amygdala FC with visual cortex, thalamus and orbitofrontal cortex. Our results do not support imbalanced cortico-limbic activity as IP for MDD. Diminished amygdala-dorsomedial prefrontal FC in relatives might indicate insufficient regulatory capacity, which appears to be compensated by ventromedial prefrontal regions. Differential task-dependent modulations of amygdala FC are discussed as a stronger involvement of automatic instead of voluntary emotional processing pathways. Reliability and etiological implications of these results should be investigated in future studies including longitudinal designs and patient-risk-control comparisons.Neuropsychopharmacology accepted article preview online, 15 March 2017. doi:10.1038/npp.2017.59. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Egypt | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
| Members of the public | 2 | 33% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Student > Master | 10 | 14% |
| Researcher | 7 | 9% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 9 | 12% |
| Unknown | 19 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 19 | 26% |
| Neuroscience | 12 | 16% |
| Medicine and Dentistry | 6 | 8% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Other | 7 | 9% |
| Unknown | 25 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#14,393,794
of 25,382,440 outputs
Outputs from Neuropsychopharmacology
#3,933
of 5,164 outputs
Outputs of similar age
#157,657
of 322,265 outputs
Outputs of similar age from Neuropsychopharmacology
#54
of 60 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,164 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.3. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.