Title |
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract – A systematic review and meta-analysis
|
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Published in |
European Journal of Cancer (1965), September 2013
|
DOI | 10.1016/j.ejca.2013.08.022 |
Pubmed ID | |
Authors |
Lorenz K. Thomas, Justo Lorenzo Bermejo, Svetlana Vinokurova, Katrin Jensen, Mariska Bierkens, Renske Steenbergen, Marion Bergmann, Magnus von Knebel Doeberitz, Miriam Reuschenbach |
Abstract |
Overexpression of the human papillomavirus (HPV) oncogenes E6 and E7 is necessary for the development of distinct lower genital tract cancers. However, secondary cellular genomic alterations are mandatory to promote progression of HPV-induced premalignant stages. We aimed at identifying the chromosomal regions most frequently gained and lost and the disease stage at which the latter occurs. These regions might be relevant for carcinogenesis and could serve as diagnostic markers to identify premalignant lesions with high progression risk towards invasive cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 22% |
Researcher | 8 | 13% |
Student > Master | 6 | 10% |
Student > Bachelor | 6 | 10% |
Other | 4 | 6% |
Other | 11 | 17% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 29% |
Biochemistry, Genetics and Molecular Biology | 9 | 14% |
Agricultural and Biological Sciences | 9 | 14% |
Immunology and Microbiology | 4 | 6% |
Computer Science | 2 | 3% |
Other | 1 | 2% |
Unknown | 20 | 32% |