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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Overview of attention for article published in Nature Genetics, September 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
9 news outlets
blogs
3 blogs
twitter
83 X users
patent
6 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
1172 Dimensions

Readers on

mendeley
1075 Mendeley
citeulike
4 CiteULike
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Title
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Published in
Nature Genetics, September 2013
DOI 10.1038/ng.2770
Pubmed ID
Abstract

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 83 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,075 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 <1%
United Kingdom 7 <1%
Spain 3 <1%
Germany 3 <1%
Sweden 2 <1%
Canada 2 <1%
Korea, Republic of 1 <1%
Austria 1 <1%
Netherlands 1 <1%
Other 7 <1%
Unknown 1039 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 211 20%
Researcher 170 16%
Student > Bachelor 138 13%
Student > Master 118 11%
Student > Doctoral Student 76 7%
Other 169 16%
Unknown 193 18%
Readers by discipline Count As %
Medicine and Dentistry 235 22%
Agricultural and Biological Sciences 208 19%
Biochemistry, Genetics and Molecular Biology 141 13%
Neuroscience 96 9%
Immunology and Microbiology 56 5%
Other 88 8%
Unknown 251 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 159. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2022.
All research outputs
#257,561
of 25,464,544 outputs
Outputs from Nature Genetics
#463
of 7,583 outputs
Outputs of similar age
#1,881
of 217,959 outputs
Outputs of similar age from Nature Genetics
#9
of 88 outputs
Altmetric has tracked 25,464,544 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 217,959 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.