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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 1998
|
| DOI | 10.1073/pnas.95.8.4584 |
| Pubmed ID | |
| Authors |
Anthony M. Ford, Caroline A. Bennett, Cathy M. Price, M. C. A. Bruin, Elisabeth R. Van Wering, Mel Greaves |
| Abstract |
The TEL (ETV6)-AML1 (CBFA2) gene fusion is the most common reciprocal chromosomal rearrangement in childhood cancer occurring in approximately 25% of the most predominant subtype of leukemia- common acute lymphoblastic leukemia. The TEL-AML1 genomic sequence has been characterized in a pair of monozygotic twins diagnosed at ages 3 years, 6 months and 4 years, 10 months with common acute lymphoblastic leukemia. The twin leukemic DNA shared the same unique (or clonotypic) but nonconstitutive TEL-AML1 fusion sequence. The most plausible explanation for this finding is a single cell origin of the TEL-AML fusion in one fetus in utero, probably as a leukemia-initiating mutation, followed by intraplacental metastasis of clonal progeny to the other twin. Clonal identity is further supported by the finding that the leukemic cells in the two twins shared an identical rearranged IGH allele. These data have implications for the etiology and natural history of childhood leukemia. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Unknown | 100 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 18% |
| Student > Master | 16 | 16% |
| Researcher | 15 | 15% |
| Student > Bachelor | 10 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 33% |
| Agricultural and Biological Sciences | 18 | 18% |
| Biochemistry, Genetics and Molecular Biology | 16 | 16% |
| Immunology and Microbiology | 5 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2013.
All research outputs
#16,741,542
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#91,769
of 101,438 outputs
Outputs of similar age
#31,465
of 33,951 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#519
of 529 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 33,951 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 529 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.