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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, September 2013
|
| DOI | 10.1073/pnas.1306285110 |
| Pubmed ID | |
| Authors |
Shilong Yang, Yao Xiao, Di Kang, Jie Liu, Yuan Li, Eivind A. B. Undheim, Julie K. Klint, Mingqiang Rong, Ren Lai, Glenn F. King |
| Abstract |
Loss-of-function mutations in the human voltage-gated sodium channel NaV1.7 result in a congenital indifference to pain. Selective inhibitors of NaV1.7 are therefore likely to be powerful analgesics for treating a broad range of pain conditions. Herein we describe the identification of µ-SLPTX-Ssm6a, a unique 46-residue peptide from centipede venom that potently inhibits NaV1.7 with an IC50 of ∼25 nM. µ-SLPTX-Ssm6a has more than 150-fold selectivity for NaV1.7 over all other human NaV subtypes, with the exception of NaV1.2, for which the selectivity is 32-fold. µ-SLPTX-Ssm6a contains three disulfide bonds with a unique connectivity pattern, and it has no significant sequence homology with any previously characterized peptide or protein. µ-SLPTX-Ssm6a proved to be a more potent analgesic than morphine in a rodent model of chemical-induced pain, and it was equipotent with morphine in rodent models of thermal and acid-induced pain. This study establishes µ-SPTX-Ssm6a as a promising lead molecule for the development of novel analgesics targeting NaV1.7, which might be suitable for treating a wide range of human pain pathologies. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 19% |
| Australia | 3 | 7% |
| United Kingdom | 3 | 7% |
| Japan | 2 | 5% |
| Netherlands | 2 | 5% |
| Bolivia, Plurinational State of | 1 | 2% |
| Switzerland | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 21 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 76% |
| Scientists | 7 | 17% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Switzerland | 1 | <1% |
| Belgium | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 208 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 45 | 21% |
| Student > Ph. D. Student | 41 | 19% |
| Student > Bachelor | 27 | 12% |
| Student > Master | 26 | 12% |
| Other | 13 | 6% |
| Other | 39 | 18% |
| Unknown | 26 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 35% |
| Medicine and Dentistry | 35 | 16% |
| Biochemistry, Genetics and Molecular Biology | 20 | 9% |
| Chemistry | 20 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Other | 21 | 10% |
| Unknown | 31 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 220. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2021.
All research outputs
#166,203
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#3,275
of 101,438 outputs
Outputs of similar age
#1,141
of 211,689 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#47
of 881 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 881 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.