| Title |
Nanotechnology for the treatment of melanoma skin cancer
|
|---|---|
| Published in |
Progress in Biomaterials, March 2017
|
| DOI | 10.1007/s40204-017-0064-z |
| Pubmed ID | |
| Authors |
Lucas B. Naves, Chetna Dhand, Jayarama Reddy Venugopal, Lakshminarayanan Rajamani, Seeram Ramakrishna, Luis Almeida |
| Abstract |
Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. This literature review intends to elucidate the possibilities to treat melanoma skin cancer using hybrid nanofibers developed by advanced electrospinning process. In this review we have shown that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells. Inhibitors of protein kinase are already available in the market for melanoma treatment and are approved by the FDA; these agents are cobimetinib, dabrafenib, ipilimumab, nivolumab, trametinib, and vemurafenib. We also report a case study involving two different approaches for targeting melanoma skin cancer therapy, namely, magnetic-based core-shell particles and electrospun mats. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Unknown | 222 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 15% |
| Student > Bachelor | 27 | 12% |
| Student > Ph. D. Student | 25 | 11% |
| Student > Postgraduate | 13 | 6% |
| Researcher | 13 | 6% |
| Other | 29 | 13% |
| Unknown | 83 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 31 | 14% |
| Biochemistry, Genetics and Molecular Biology | 25 | 11% |
| Chemistry | 16 | 7% |
| Engineering | 15 | 7% |
| Medicine and Dentistry | 11 | 5% |
| Other | 34 | 15% |
| Unknown | 91 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2017.
All research outputs
#18,539,663
of 22,961,203 outputs
Outputs from Progress in Biomaterials
#27
of 47 outputs
Outputs of similar age
#235,310
of 308,429 outputs
Outputs of similar age from Progress in Biomaterials
#1
of 2 outputs
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