| Title |
Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile
|
|---|---|
| Published in |
Genes & Nutrition, September 2013
|
| DOI | 10.1007/s12263-013-0356-4 |
| Pubmed ID | |
| Authors |
Jose C. E. Serrano, David De Lorenzo, Anna Cassanye, Meritxell Martín-Gari, Alberto Espinel, Marco Antonio Delgado, Reinald Pamplona, Manuel Portero-Otin |
| Abstract |
Vitamin D receptor polymorphisms may predispose that not all individuals could have benefits from the nutritional supplementation of 25-hydroxyvitamin D. Furthermore, vitamin D-related cardiovascular effects may also be influenced by soy isoflavones considered endocrine regulators of cardiovascular homeostasis. To find possible gene-diet interactions by evaluating individualized lipid metabolism benefits from an increase in soy and 25-hydroxyvitamin D intake, 106 healthy individuals, genotyped for vitamin D receptor (VDR) gene polymorphism rs1544410 (BsmI) were randomly assigned to either no intake, to daily 250 mL or 500 mL of a 25-hydroxyvitamin D supplemented SB for 2 months. The soybean beverage induced differences in cardiovascular risk factors (lipid profile, blood pressure, TNFα and MCP-1), as well as vitamin D metabolites in a dose-gene-dependent relation. Thus, VDR BsmI polymorphism affected individual response being the GG genotype the ones that showed dose-dependent manner responsiveness in the reduction in total cholesterol, LDL and triglycerides in comparison with the AA/AG genotype. These differences were associated with increased plasma levels of 1α,25-dyhydroxyvitamin D3 in the carriers of the GG genotype. It was concluded that metabolic response to 25-hydroxyvitamin D and soybean supplementation is dependent on VDR BsmI GG genotype due to a higher conversion rate from vitamin D precursors. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 39 | 40% |
| Student > Bachelor | 16 | 16% |
| Student > Ph. D. Student | 7 | 7% |
| Researcher | 5 | 5% |
| Professor > Associate Professor | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 31% |
| Environmental Science | 17 | 17% |
| Medicine and Dentistry | 13 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Nursing and Health Professions | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 15 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2015.
All research outputs
#15,280,625
of 22,723,682 outputs
Outputs from Genes & Nutrition
#240
of 388 outputs
Outputs of similar age
#124,774
of 203,246 outputs
Outputs of similar age from Genes & Nutrition
#1
of 2 outputs
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