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Mendeley readers
Attention Score in Context
| Title |
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
|
|---|---|
| Published in |
Cancer Cell, March 2003
|
| DOI | 10.1016/s1535-6108(03)00048-5 |
| Pubmed ID | |
| Authors |
Claus Storgaard Sørensen, Randi G. Syljuåsen, Jacob Falck, Tine Schroeder, Lars Rönnstrand, Kum Kum Khanna, Bin-Bing Zhou, Jiri Bartek, Jiri Lukas |
| Abstract |
Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we show that chemical or genetic ablation of human Chk1 triggered supraphysiological accumulation of the S phase-promoting Cdc25A phosphatase, prevented ionizing radiation (IR)-induced degradation of Cdc25A, and caused radioresistant DNA synthesis (RDS). The basal turnover of Cdc25A operating in unperturbed S phase required Chk1-dependent phosphorylation of serines 123, 178, 278, and 292. IR-induced acceleration of Cdc25A proteolysis correlated with increased phosphate incorporation into these residues generated by a combined action of Chk1 and Chk2 kinases. Finally, phosphorylation of Chk1 by ATM was required to fully accelerate the IR-induced degradation of Cdc25A. Our results provide evidence that the mammalian S phase checkpoint functions via amplification of physiologically operating, Chk1-dependent mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 256 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| Netherlands | 1 | <1% |
| Indonesia | 1 | <1% |
| Spain | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 246 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 29% |
| Researcher | 36 | 14% |
| Student > Master | 34 | 13% |
| Student > Bachelor | 27 | 11% |
| Student > Doctoral Student | 15 | 6% |
| Other | 28 | 11% |
| Unknown | 41 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 94 | 37% |
| Biochemistry, Genetics and Molecular Biology | 75 | 29% |
| Medicine and Dentistry | 18 | 7% |
| Chemistry | 6 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 11 | 4% |
| Unknown | 48 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2019.
All research outputs
#3,798,066
of 25,371,288 outputs
Outputs from Cancer Cell
#1,847
of 3,149 outputs
Outputs of similar age
#5,832
of 62,542 outputs
Outputs of similar age from Cancer Cell
#6
of 24 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.