| Title |
Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood
|
|---|---|
| Published in |
Brain Imaging and Behavior, September 2013
|
| DOI | 10.1007/s11682-013-9260-1 |
| Pubmed ID | |
| Authors |
Vanessa Douet, Linda Chang, Christine Cloak, Thomas Ernst |
| Abstract |
Human brain development has been studied intensively with neuroimaging. However, little is known about how genes influence developmental brain trajectories, even though a significant number of genes (about 10,000, or approximately one-third) in the human genome are expressed primarily in the brain and during brain development. Interestingly, in addition to showing differential expression among tissues, many genes are differentially expressed across the ages (e.g., antagonistic pleiotropy). Age-specific gene expression plays an important role in several critical events in brain development, including neuronal cell migration, synaptogenesis and neurotransmitter receptor specificity, as well as in aging and neurodegenerative disorders (e.g., Alzheimer disease or amyotrophic lateral sclerosis). In addition, the majority of psychiatric and mental disorders are polygenic, and many have onsets during childhood and adolescence. In this review, we summarize the major findings from neuroimaging studies that link genetics with brain development, from infancy to young adulthood. Specifically, we focus on the heritability of brain structures across the ages, age-related genetic influences on brain development and sex-specific developmental trajectories. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Cuba | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 125 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 26% |
| Researcher | 23 | 18% |
| Student > Bachelor | 13 | 10% |
| Student > Master | 12 | 9% |
| Student > Doctoral Student | 5 | 4% |
| Other | 14 | 11% |
| Unknown | 28 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 22 | 17% |
| Neuroscience | 18 | 14% |
| Medicine and Dentistry | 17 | 13% |
| Agricultural and Biological Sciences | 10 | 8% |
| Biochemistry, Genetics and Molecular Biology | 10 | 8% |
| Other | 12 | 9% |
| Unknown | 40 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2023.
All research outputs
#14,849,289
of 25,761,363 outputs
Outputs from Brain Imaging and Behavior
#487
of 1,188 outputs
Outputs of similar age
#114,271
of 218,743 outputs
Outputs of similar age from Brain Imaging and Behavior
#10
of 25 outputs
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