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Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

Overview of attention for article published in International Journal for Parasitology, July 2013
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Title
Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes
Published in
International Journal for Parasitology, July 2013
DOI 10.1016/j.ijpara.2013.06.004
Pubmed ID
Authors

Andrew R. Williams, Sara E. Zakutansky, Kazutoyo Miura, Matthew D.J. Dicks, Thomas S. Churcher, Kerry E. Jewell, Aisling M. Vaughan, Alison V. Turner, Melissa C. Kapulu, Kristin Michel, Carole A. Long, Robert E. Sinden, Adrian V.S. Hill, Simon J. Draper, Sumi Biswas

Abstract

The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
United Kingdom 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 28%
Student > Master 8 21%
Student > Ph. D. Student 7 18%
Other 4 10%
Librarian 2 5%
Other 4 10%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 44%
Medicine and Dentistry 4 10%
Biochemistry, Genetics and Molecular Biology 4 10%
Veterinary Science and Veterinary Medicine 1 3%
Linguistics 1 3%
Other 6 15%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2013.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from International Journal for Parasitology
#1,878
of 2,078 outputs
Outputs of similar age
#157,875
of 207,998 outputs
Outputs of similar age from International Journal for Parasitology
#28
of 30 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,078 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,998 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.