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Mendeley readers
Attention Score in Context
| Title |
Plasmodium Gametocyte Inhibition Identified from a Natural-Product-Based Fragment Library
|
|---|---|
| Published in |
ACS Chemical Biology, October 2013
|
| DOI | 10.1021/cb400582b |
| Pubmed ID | |
| Authors |
Hoan Vu, Catherine Roullier, Marc Campitelli, Katharine R. Trenholme, Donald L. Gardiner, Katherine T. Andrews, Tina Skinner-Adams, Gregory J. Crowther, Wesley C. Van Voorhis, Ronald J. Quinn |
| Abstract |
Fragment-based screening is commonly used to identify compounds with relatively weak but efficient localized binding to protein surfaces. We used mass spectrometry to study fragment-sized three-dimensional natural products. We identified seven securinine-related compounds binding to Plasmodium falciparum 2'-deoxyuridine 5'-triphosphate nucleotidohydrolase (PfdUTPase). Securinine bound allosterically to PfdUTPase, enhancing enzyme activity and inhibiting viability of both P. falciparum gametocyte (sexual) and blood (asexual) stage parasites. Our results provide a new insight into mechanisms that may be applicable to transmission-blocking agents. |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| China | 1 | 2% |
| Unknown | 52 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 24% |
| Researcher | 13 | 24% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 25 | 45% |
| Agricultural and Biological Sciences | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Medicine and Dentistry | 4 | 7% |
| Chemical Engineering | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#4,132,303
of 22,725,280 outputs
Outputs from ACS Chemical Biology
#917
of 3,250 outputs
Outputs of similar age
#38,360
of 207,470 outputs
Outputs of similar age from ACS Chemical Biology
#12
of 60 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,250 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,470 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.