| Title |
Euterpe oleracea Mart. seed extract protects against renal injury in diabetic and spontaneously hypertensive rats: role of inflammation and oxidative stress
|
|---|---|
| Published in |
European Journal of Nutrition, January 2017
|
| DOI | 10.1007/s00394-016-1371-1 |
| Pubmed ID | |
| Authors |
Viviane da Silva Cristino Cordeiro, Graziele Freitas de Bem, Cristiane Aguiar da Costa, Izabelle Barcellos Santos, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Ana Paula Machado da Rocha, Jorge José de Carvalho, Roberto Soares de Moura, Angela Castro Resende |
| Abstract |
Euterpe oleracea Mart. (açaí) seed extract (ASE), through its anti-hypertensive, antioxidant and anti-inflammatory properties, may be useful to treat or prevent human diseases. Several evidences suggest that oxidative stress and inflammation contribute to the pathogenesis of diabetic nephropathy; therefore, we tested the hypothesis that ASE (200 mg/kg(-1)day(-1)) prevents diabetes and hypertension-related oxidative stress and inflammation, attenuating renal injury. Male rats with streptozotocin (STZ)-induced diabetes (D), and spontaneously hypertensive rats with STZ-induced diabetes (DH) were treated daily with tap water or ASE (D + ASE and DH + ASE, respectively) for 45 days. The control (C) and hypertensive (H) animals received water. The elevated serum levels of urea and creatinine in D and DH, and increased albumin excretion in HD were reduced by ASE. Total glomeruli number in D and DH, were increased by ASE that also reduced renal fibrosis in both groups by decreasing collagen IV and TGF-β1 expression. ASE improved biomarkers of renal filtration barrier (podocin and nephrin) in D and DH groups and prevented the increased expression of caspase-3, IL-6, TNF-α and MCP-1 in both groups. ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx). ASE substantially reduced renal injury and prevented renal dysfunction by reducing inflammation, oxidative stress and improving the renal filtration barrier, providing a nutritional resource for prevention of diabetic and hypertensive-related nephropathy. |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 78 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 19% |
| Student > Master | 13 | 17% |
| Student > Doctoral Student | 8 | 10% |
| Student > Ph. D. Student | 5 | 6% |
| Professor | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 24 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Nursing and Health Professions | 7 | 9% |
| Agricultural and Biological Sciences | 6 | 8% |
| Medicine and Dentistry | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Other | 18 | 23% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2017.
All research outputs
#20,411,380
of 22,961,203 outputs
Outputs from European Journal of Nutrition
#2,137
of 2,400 outputs
Outputs of similar age
#353,249
of 417,459 outputs
Outputs of similar age from European Journal of Nutrition
#29
of 33 outputs
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