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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), March 2017
|
| DOI | 10.1016/j.chom.2017.03.001 |
| Pubmed ID | |
| Authors |
Tiffany C. Scharschmidt, Kimberly S. Vasquez, Mariela L. Pauli, Elizabeth G. Leitner, Kevin Chu, Hong-An Truong, Margaret M. Lowe, Robert Sanchez Rodriguez, Niwa Ali, Zoltan G. Laszik, Justin L. Sonnenburg, Sarah E. Millar, Michael D. Rosenblum |
| Abstract |
Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development facilitates the accumulation of Tregs in neonatal skin and that upon skin entry these cells localize to HFs, a primary reservoir for skin commensals. Further, germ-free neonates had reduced skin Tregs indicating that commensal microbes augment Treg accumulation. We identified Ccl20 as a HF-derived, microbiota-dependent chemokine and found its receptor, Ccr6, to be preferentially expressed by Tregs in neonatal skin. The Ccl20-Ccr6 pathway mediated Treg migration in vitro and in vivo. Thus, HF morphogenesis, commensal microbe colonization, and local chemokine production work in concert to recruit Tregs into neonatal skin, thereby establishing this tissue Treg niche early in life. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 39% |
| United Kingdom | 3 | 10% |
| India | 2 | 6% |
| France | 1 | 3% |
| Canada | 1 | 3% |
| Netherlands | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Unknown | 10 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 17 | 55% |
| Members of the public | 10 | 32% |
| Practitioners (doctors, other healthcare professionals) | 3 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| France | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 221 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 21% |
| Researcher | 44 | 20% |
| Student > Bachelor | 18 | 8% |
| Student > Master | 16 | 7% |
| Student > Doctoral Student | 15 | 7% |
| Other | 30 | 13% |
| Unknown | 54 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 57 | 25% |
| Agricultural and Biological Sciences | 38 | 17% |
| Biochemistry, Genetics and Molecular Biology | 32 | 14% |
| Medicine and Dentistry | 18 | 8% |
| Neuroscience | 5 | 2% |
| Other | 14 | 6% |
| Unknown | 60 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2018.
All research outputs
#1,182,496
of 25,382,440 outputs
Outputs from Cell Host & Microbe (Science Direct)
#779
of 2,627 outputs
Outputs of similar age
#23,541
of 322,668 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#17
of 53 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.