| Title |
Mechanisms of brain glucocorticoid resistance in stress-induced psychopathologies
|
|---|---|
| Published in |
Biochemistry, March 2017
|
| DOI | 10.1134/s0006297917030142 |
| Pubmed ID | |
| Authors |
V. M. Merkulov, T. I. Merkulova, N. P. Bondar |
| Abstract |
Exposure to stress activates the hypothalamic-pituitary-adrenal axis and leads to increased levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal dysfunction, decreases the density of synapses, and impairs neuronal plasticity. Decreased sensitivity to glucocorticoids (glucocorticoid resistance) that develops as a result of chronic stress is one of the characteristic features of stress-induced psychopathologies. In this article, we reviewed the published data on proposed molecular mechanisms that contribute to the development of glucocorticoid resistance in brain, including changes in the expression of the glucocorticoid receptor (GR) gene, biosynthesis of GR isoforms, and GR posttranslational modifications. We also present data on alterations in the expression of the FKBP5 gene encoding the main component of cell ultra-short negative feedback loop of GC signaling regulation. Recent discoveries on stress- and GR-induced changes in epigenetic modification patterns as well as normalizing action of antidepressants are discussed. GR and FKBP5 gene polymorphisms associated with stress-induced psychopathologies are described, and their role in glucocorticoid resistance is discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 97 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 13% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Master | 9 | 9% |
| Researcher | 8 | 8% |
| Student > Postgraduate | 8 | 8% |
| Other | 21 | 22% |
| Unknown | 27 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 16% |
| Agricultural and Biological Sciences | 12 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Medicine and Dentistry | 8 | 8% |
| Psychology | 8 | 8% |
| Other | 7 | 7% |
| Unknown | 35 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2024.
All research outputs
#16,051,091
of 25,382,440 outputs
Outputs from Biochemistry
#19,041
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Outputs of similar age
#185,569
of 321,626 outputs
Outputs of similar age from Biochemistry
#54
of 120 outputs
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