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Discovery and refinement of loci associated with lipid levels

Overview of attention for article published in Nature Genetics, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
12 news outlets
blogs
5 blogs
twitter
24 X users
patent
6 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
2601 Dimensions

Readers on

mendeley
1326 Mendeley
citeulike
7 CiteULike
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Title
Discovery and refinement of loci associated with lipid levels
Published in
Nature Genetics, October 2013
DOI 10.1038/ng.2797
Pubmed ID
Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,326 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 <1%
United Kingdom 10 <1%
Switzerland 2 <1%
Mexico 2 <1%
Sweden 2 <1%
Canada 2 <1%
Finland 2 <1%
South Africa 1 <1%
France 1 <1%
Other 10 <1%
Unknown 1284 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 281 21%
Researcher 277 21%
Student > Master 119 9%
Student > Bachelor 94 7%
Other 67 5%
Other 261 20%
Unknown 227 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 290 22%
Medicine and Dentistry 277 21%
Agricultural and Biological Sciences 254 19%
Computer Science 23 2%
Nursing and Health Professions 22 2%
Other 158 12%
Unknown 302 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2023.
All research outputs
#301,789
of 25,081,505 outputs
Outputs from Nature Genetics
#568
of 7,528 outputs
Outputs of similar age
#2,261
of 215,645 outputs
Outputs of similar age from Nature Genetics
#12
of 87 outputs
Altmetric has tracked 25,081,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,528 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,645 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.