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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Are nicotinic acetylcholine receptors coupled to G proteins?
|
|---|---|
| Published in |
BioEssays, October 2013
|
| DOI | 10.1002/bies.201300082 |
| Pubmed ID | |
| Authors |
Nadine Kabbani, Jacob C. Nordman, Brian A. Corgiat, Daniel P. Veltri, Amarda Shehu, Victoria A. Seymour, David J. Adams |
| Abstract |
It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand-gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 92 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 23% |
| Student > Bachelor | 12 | 13% |
| Student > Master | 11 | 12% |
| Researcher | 9 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 18 | 19% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 22% |
| Neuroscience | 18 | 19% |
| Biochemistry, Genetics and Molecular Biology | 18 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Chemistry | 5 | 5% |
| Other | 8 | 9% |
| Unknown | 18 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2023.
All research outputs
#6,919,921
of 24,571,708 outputs
Outputs from BioEssays
#1,120
of 2,970 outputs
Outputs of similar age
#59,242
of 215,309 outputs
Outputs of similar age from BioEssays
#10
of 28 outputs
Altmetric has tracked 24,571,708 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,970 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.