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Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

Overview of attention for article published in Behavioural Brain Research, October 2013
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice
Published in
Behavioural Brain Research, October 2013
DOI 10.1016/j.bbr.2013.09.049
Pubmed ID
Authors

Randal X. Moldrich, Gayeshika Leanage, David She, Elliot Dolan-Evans, Michael Nelson, Nargis Reza, David C. Reutens

Abstract

Exposure to sodium valproate (VPA) in utero increases the risk of language impairment and a diagnosis of autism spectrum disorder (ASD). Mice exposed to VPA while in utero have also shown postnatal social deficits. Inhibition of histone deacetylase (HDAC) is one of VPA's many biological effects. The main objective of this study was to test the hypothesis that HDAC inhibition causes these behavioral outcomes following prenatal VPA exposure in mice. We exposed embryonic mice to VPA, the HDAC inhibitor trichostatin A (TSA), or vehicle controls. TSA (1mg/kg) inhibited HDAC in embryonic tissue at a level comparable to 600 mg/kg VPA, resulting in significant increases in histone H3 and H4 acetylation, and histone H3 lysine 4 tri-methylation. Postnatally, decreases in ultrasonic vocalization, olfactory motivation and sociability were observed in TSA and VPA-exposed pups. Treated mice exhibited elevated digging and grooming suggestive of mild restrictive and repetitive behaviors. Olfactory social preference, social novelty and habituation were normal. Together, these data indicate that embryonic HDAC inhibition alone can cause abnormal social behaviors in mice. This result serves as a molecular understanding of infant outcomes following mild VPA exposure in utero.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 <1%
Brazil 1 <1%
Unknown 170 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 21%
Student > Master 24 14%
Student > Bachelor 23 13%
Researcher 14 8%
Professor > Associate Professor 10 6%
Other 30 17%
Unknown 35 20%
Readers by discipline Count As %
Neuroscience 32 19%
Psychology 24 14%
Medicine and Dentistry 19 11%
Agricultural and Biological Sciences 16 9%
Biochemistry, Genetics and Molecular Biology 8 5%
Other 29 17%
Unknown 44 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2022.
All research outputs
#7,142,322
of 25,654,806 outputs
Outputs from Behavioural Brain Research
#1,443
of 4,996 outputs
Outputs of similar age
#60,191
of 221,345 outputs
Outputs of similar age from Behavioural Brain Research
#17
of 68 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,996 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,345 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.