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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
|
|---|---|
| Published in |
Nature Genetics, October 2013
|
| DOI | 10.1038/ng.2792 |
| Pubmed ID | |
| Authors |
Christopher J Lessard, He Li, Indra Adrianto, John A Ice, Astrid Rasmussen, Kiely M Grundahl, Jennifer A Kelly, Mikhail G Dozmorov, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G Brun, Lasse G Gøransson, Erna Harboe, Joel M Guthridge, Kenneth M Kaufman, Marika Kvarnström, Helmi Jazebi, Deborah S Cunninghame Graham, Martha E Grandits, Abu N M Nazmul-Hossain, Ketan Patel, Adam J Adler, Jacen S Maier-Moore, A Darise Farris, Michael T Brennan, James A Lessard, James Chodosh, Rajaram Gopalakrishnan, Kimberly S Hefner, Glen D Houston, Andrew J W Huang, Pamela J Hughes, David M Lewis, Lida Radfar, Michael D Rohrer, Donald U Stone, Jonathan D Wren, Timothy J Vyse, Patrick M Gaffney, Judith A James, Roald Omdal, Marie Wahren-Herlenius, Gabor G Illei, Torsten Witte, Roland Jonsson, Maureen Rischmueller, Lars Rönnblom, Gunnel Nordmark, Wan-Fai Ng, Xavier Mariette, Juan-Manuel Anaya, Nelson L Rhodus, Barbara M Segal, R Hal Scofield, Courtney G Montgomery, John B Harley, Kathy L Sivils |
| Abstract |
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Australia | 2 | 22% |
| Canada | 1 | 11% |
| India | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 1 | 11% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 1 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 302 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Saudi Arabia | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 291 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 64 | 21% |
| Researcher | 54 | 18% |
| Student > Bachelor | 25 | 8% |
| Student > Master | 21 | 7% |
| Professor | 18 | 6% |
| Other | 64 | 21% |
| Unknown | 56 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 26% |
| Agricultural and Biological Sciences | 60 | 20% |
| Biochemistry, Genetics and Molecular Biology | 39 | 13% |
| Immunology and Microbiology | 22 | 7% |
| Neuroscience | 6 | 2% |
| Other | 30 | 10% |
| Unknown | 66 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#1,161,186
of 25,058,660 outputs
Outputs from Nature Genetics
#1,887
of 7,526 outputs
Outputs of similar age
#10,348
of 215,539 outputs
Outputs of similar age from Nature Genetics
#35
of 87 outputs
Altmetric has tracked 25,058,660 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,526 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.