| Title |
Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, July 2007
|
| DOI | 10.1007/s11010-007-9554-y |
| Pubmed ID | |
| Authors |
Bradford J. Scanlan, Blaine Tuft, Justin E. Elfrey, Allen Smith, Aiping Zhao, Motoko Morimoto, Joanna J. Chmielinska, Maria Isabel Tejero-Taldo, Iu Tong Mak, William B. Weglicki, Terez Shea-Donohue |
| Abstract |
The aim of this study was to determine the effect of magnesium deficiency on small intestinal morphology and function. Rats were assigned to 4 groups and placed on magnesium sufficient or deficient diet for 1 or 3 weeks. Infiltration of neutrophils and mucosal injury were assessed in stained sections of small intestine. Magnesium deficiency alone induced a significant increase in neutrophil infiltration and increased vascular ICAM-1 expression, in the absence of changes in mucosal injury or expression of proinflammatory mediators. Magnesium deficiency was associated with hyposecretory epithelial cell responses and vascular macromolecular leak in the small intestine and lung, which was attributed partly to reduced expression of NOS-3. To determine the effect of hypomagnesmia on the intestinal responses to a known oxidative stress, groups of rats were randomized to either sham operation or superior mesenteric artery occlusion for 10 (non-injurious) or 30 (injurious) minutes followed by a 1- or 4-hour reperfusion period. In response to mesenteric ischemia/reperfusion, deficient rats showed exaggerated PMN influx, but similar mucosal injury. Intestinal ischemia in sufficient animals induced vascular macromolecular leak in the small intestine and lung at 4 hours of reperfusion, with levels similar to those observed in untreated deficient rats. Acute magnesium repletion of deficient rats 24 h before surgery attenuated the exaggerated inflammation in deficient rats. These data show that magnesium deficiency induced a subclinical inflammation in the small intestine in the absence of mucosal injury, but with significant functional changes in local and remote organs and increased sensitivity to oxidative stress. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 15% |
| United States | 3 | 15% |
| Australia | 1 | 5% |
| New Zealand | 1 | 5% |
| Georgia | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 10 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 80% |
| Practitioners (doctors, other healthcare professionals) | 3 | 15% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 5% |
| Unknown | 20 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 24% |
| Student > Ph. D. Student | 3 | 14% |
| Other | 2 | 10% |
| Professor > Associate Professor | 2 | 10% |
| Student > Bachelor | 2 | 10% |
| Other | 2 | 10% |
| Unknown | 5 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 43% |
| Agricultural and Biological Sciences | 5 | 24% |
| Chemistry | 1 | 5% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2022.
All research outputs
#2,686,737
of 25,315,460 outputs
Outputs from Molecular and Cellular Biochemistry
#77
of 2,493 outputs
Outputs of similar age
#6,009
of 74,560 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 19 outputs
Altmetric has tracked 25,315,460 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,493 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.