| Title |
Atrogin-1, MuRF-1, and sarcopenia
|
|---|---|
| Published in |
Endocrine, July 2012
|
| DOI | 10.1007/s12020-012-9751-7 |
| Pubmed ID | |
| Authors |
Jonathan P. Gumucio, Christopher L. Mendias |
| Abstract |
Sarcopenia is one of the leading causes of disability in the elderly. Despite the growing prevalence of sarcopenia, the molecular mechanisms that control aging-related changes in muscle mass are not fully understood. The ubiquitin proteasome system is one of the major pathways that regulate muscle protein degradation, and this system plays a central role in controlling muscle size. Atrogin-1 and MuRF-1 are two E3 ubiquitin ligases that are important regulators of ubiquitin-mediated protein degradation in skeletal muscle. In this review, we will discuss: (i) aging-related changes to skeletal muscle structure and function; (ii) the regulation of protein synthesis and protein degradation by IGF-1, TGF-β, and myostatin, with emphasis on the control of atrogin-1 and MuRF-1 expression; and (iii) the potential for modulating atrogin-1 and MuRF-1 expression to treat or prevent sarcopenia. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 2 | 29% |
| United Kingdom | 2 | 29% |
| United States | 1 | 14% |
| Portugal | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 43% |
| Scientists | 2 | 29% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 279 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| Brazil | 2 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 272 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 51 | 18% |
| Student > Ph. D. Student | 43 | 15% |
| Student > Bachelor | 40 | 14% |
| Researcher | 27 | 10% |
| Student > Doctoral Student | 14 | 5% |
| Other | 37 | 13% |
| Unknown | 67 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 19% |
| Agricultural and Biological Sciences | 49 | 18% |
| Medicine and Dentistry | 44 | 16% |
| Sports and Recreations | 24 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
| Other | 25 | 9% |
| Unknown | 73 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2023.
All research outputs
#1,619,291
of 24,709,170 outputs
Outputs from Endocrine
#74
of 1,846 outputs
Outputs of similar age
#9,288
of 167,700 outputs
Outputs of similar age from Endocrine
#1
of 17 outputs
Altmetric has tracked 24,709,170 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,846 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,700 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.