| Title |
Cancer susceptibility variants and the risk of adult glioma in a US case–control study
|
|---|---|
| Published in |
Journal of Neuro-Oncology, January 2011
|
| DOI | 10.1007/s11060-010-0506-0 |
| Pubmed ID | |
| Authors |
Kathleen M. Egan, Reid C. Thompson, L. B. Nabors, Jeffrey J. Olson, Daniel J. Brat, Renato V. LaRocca, Steven Brem, Paul L. Moots, Melissa H. Madden, James E. Browning, Y. Ann Chen |
| Abstract |
Malignant gliomas are the most common and deadly brain tumors. Although their etiology remains elusive, recent studies have narrowed the search for genetic loci that influence risk. We examined variants implicated in recent cancer genome-wide association studies (GWAS) for associations with glioma risk in a US case-control study. Cases were identified from neurosurgical and neuro-oncology clinics at major academic centers in the Southeastern US. Controls were identified from the community or were friends or other associates of cases. We examined a total of 191 susceptibility variants in genes identified in published cancer GWAS including glioma. A total of 639 glioma cases and 649 controls, all Caucasian, were included in analysis. Cases were enrolled a median of 1 month following diagnosis. Among glioma GWAS-identified variants, we detected associations in CDKN2B, RTEL1, TERT and PHLDB1, whereas we did not find overall associations for CCDC26. Results showed clear heterogeneity according to histologic subtypes of glioma, with TERT and RTEL variants a feature of astrocytic tumors and glioblastoma (GBM), CCDC26 and PHLDB1 variants a feature of astrocytic and oligodendroglial tumors, and CDKN2B variants most prominent in GBM. No examined variant in other cancer GWAS was found to be related to risk after adjustment for multiple comparisons. These results suggest that GWAS-identified SNPs in glioma mark different molecular etiologies in glioma. Stratification by broad histological subgroups may shed light on molecular mechanisms and assist in the discovery of novel loci in future studies of genetic susceptibility variants in glioma. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| United States | 1 | 4% |
| Australia | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 21 | 84% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 20% |
| Student > Ph. D. Student | 4 | 16% |
| Professor > Associate Professor | 3 | 12% |
| Student > Master | 3 | 12% |
| Professor | 2 | 8% |
| Other | 5 | 20% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 32% |
| Agricultural and Biological Sciences | 6 | 24% |
| Medicine and Dentistry | 5 | 20% |
| Nursing and Health Professions | 1 | 4% |
| Unknown | 5 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2013.
All research outputs
#3,720,291
of 22,725,280 outputs
Outputs from Journal of Neuro-Oncology
#327
of 2,960 outputs
Outputs of similar age
#24,668
of 180,554 outputs
Outputs of similar age from Journal of Neuro-Oncology
#3
of 11 outputs
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So far Altmetric has tracked 2,960 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 88% of its peers.
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