| Title |
Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes
|
|---|---|
| Published in |
Diabetologia, March 2017
|
| DOI | 10.1007/s00125-017-4233-3 |
| Pubmed ID | |
| Authors |
Tor I. Hansen, Sandra E. Olsen, Elise C. D. Haferstrom, Trond Sand, Brian M. Frier, Asta K. Håberg, Marit R. Bjørgaas |
| Abstract |
The aim of this study was to compare cognitive function in adults with type 1 diabetes who have impaired awareness of hypoglycaemia with those who have normal awareness of hypoglycaemia. A putative association was sought between cognitive test scores and a history of severe hypoglycaemia. A total of 68 adults with type 1 diabetes were included: 33 had impaired and 35 had normal awareness of hypoglycaemia, as confirmed by formal testing. The groups were matched for age, sex and diabetes duration. Cognitive tests of verbal memory, object-location memory, pattern separation, executive function, working memory and processing speed were administered. Participants with impaired awareness of hypoglycaemia scored significantly lower on the verbal and object-location memory tests and on the pattern separation test (Cohen's d -0.86 to -0.55 [95% CI -1.39, -0.05]). Participants with impaired awareness of hypoglycaemia had reduced planning ability task scores, although the difference was not statistically significant (Cohen's d 0.57 [95% CI 0, 1.14]). Frequency of exposure to severe hypoglycaemia correlated with the number of cognitive tests that had not been performed according to instructions. Impaired awareness of hypoglycaemia was associated with diminished learning, memory and pattern separation. These cognitive tasks all depend on the hippocampus, which is vulnerable to neuroglycopenia. The findings suggest that hypoglycaemia contributes to the observed correlation between impaired awareness of hypoglycaemia and impaired cognition. |
X Demographics
The data shown below were collected from the profiles of 52 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 18 | 35% |
| Spain | 6 | 12% |
| United States | 2 | 4% |
| Denmark | 1 | 2% |
| India | 1 | 2% |
| Germany | 1 | 2% |
| Finland | 1 | 2% |
| Mexico | 1 | 2% |
| Unknown | 21 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 62% |
| Practitioners (doctors, other healthcare professionals) | 10 | 19% |
| Scientists | 9 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 20% |
| Student > Bachelor | 10 | 17% |
| Student > Ph. D. Student | 7 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Researcher | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 27% |
| Neuroscience | 8 | 14% |
| Psychology | 7 | 12% |
| Sports and Recreations | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2017.
All research outputs
#785,812
of 25,732,188 outputs
Outputs from Diabetologia
#403
of 5,376 outputs
Outputs of similar age
#16,077
of 321,983 outputs
Outputs of similar age from Diabetologia
#6
of 63 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.