Title |
Possible Impact of Cytomegalovirus-Specific CD8+ T Cells on Immune Reconstitution and Conversion to Complete Donor Chimerism after Allogeneic Stem Cell Transplantation
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Published in |
Transplantation and Cellular Therapy, March 2017
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DOI | 10.1016/j.bbmt.2017.03.027 |
Pubmed ID | |
Authors |
Justyna Ogonek, Pavankumar Varanasi, Susanne Luther, Patrick Schweier, Wolfgang Kühnau, Gudrun Göhring, Elke Dammann, Michael Stadler, Arnold Ganser, Sylvia Borchers, Ulrike Koehl, Eva M. Weissinger, Lothar Hambach |
Abstract |
Complete donor chimerism is strongly associated with complete remission after allogeneic stem cell transplantation (allo-SCT) in patients with hematological malignancies. Donor-derived allo-immune responses are eliminating the residual host hematopoiesis and thereby mediate the conversion to complete donor chimerism. Recently, CMV reactivation has been described to enhance overall T-cell reconstitution, to increase graft-versus-host disease (GvHD) incidence and to reduce the leukemia relapse risk. However, the link between CMV and allo-immune responses is still unclear. Here, we studied the relationship between CMV-specific immunity, overall T-cell reconstitution and residual host chimerism in 106 CMV-seropositive patients transplanted after reduced intensity conditioning (RIC) including anti-thymocyte globulin (ATG). In accordance with previous reports, the recovery of CMV-specific cytotoxic T-cells (CMV-CTLs) was more frequent in CMV-seropositive recipients (R) transplanted from CMV-seropositive than from seronegative donors (D). However, once CMV-CTLs were detectable, the reconstitution of CMV-specific CTLs was comparable in CMV R+/D- and R+/D+ patients. CD3+ and CD8+ T-cell reconstitution was significantly faster in patients with CMV-CTLs than in patients without CMV-CTLs both in the CMV R+/D- and R+/D+ setting. Moreover, CMV-CTL numbers correlated with CD3+ and CD8+ T-cell numbers in both settings. Finally, presence of CMV-CTLs was associated with low host chimerism levels three months after allo-SCT. In conclusion, our data are providing a first indication that CMV-CTLs in CMV-seropositive patients might trigger the reconstitution of T-cells and allo-immune responses reflected by the conversion to complete donor chimerism. |
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Mendeley readers
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Student > Doctoral Student | 6 | 22% |
Student > Ph. D. Student | 4 | 15% |
Professor > Associate Professor | 3 | 11% |
Student > Bachelor | 2 | 7% |
Other | 2 | 7% |
Other | 7 | 26% |
Unknown | 3 | 11% |
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Immunology and Microbiology | 5 | 19% |
Agricultural and Biological Sciences | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 4 | 15% |