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Can Immunohistochemistry Serve as an Alternative to Subjective Histopathological Diagnosis of Oral Epithelial Dysplasia?

Overview of attention for article published in Biomarkers in Cancer, October 2013
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Title
Can Immunohistochemistry Serve as an Alternative to Subjective Histopathological Diagnosis of Oral Epithelial Dysplasia?
Published in
Biomarkers in Cancer, October 2013
DOI 10.4137/bic.s12951
Pubmed ID
Authors

Ahmad A. AbdulMajeed, Camile S. Farah

Abstract

Many attempts have been made to identify objective molecular biomarkers to diagnose and prognosticate oral epithelial dysplasia (OED) because histopathological interpretation is subjective and lacks sensitivity. The majority of these efforts describe changes in gene expression at protein level in OED as determined by immunohistochemistry (IHC). However, the literature on these putative markers of oral cancer progression is vast and varied. The main purpose of this article is to review current knowledge on biomarkers of protein expression for OED by IHC approaches. We further discuss these findings in terms of the proposed essential hallmarks of cancer cells to better understand their role in oral oncogenesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Researcher 4 17%
Student > Master 3 13%
Student > Bachelor 2 9%
Professor 2 9%
Other 5 22%
Unknown 2 9%
Readers by discipline Count As %
Medicine and Dentistry 12 52%
Engineering 3 13%
Agricultural and Biological Sciences 1 4%
Environmental Science 1 4%
Social Sciences 1 4%
Other 1 4%
Unknown 4 17%