| Title |
The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2016
|
| DOI | 10.1007/s00018-016-2386-8 |
| Pubmed ID | |
| Authors |
Xin Meng, Jack Clews, Vasileios Kargas, Xiaomeng Wang, Robert C. Ford |
| Abstract |
The cystic fibrosis transmembrane conductance regulator (CFTR) is responsible for the disease cystic fibrosis (CF). It is a membrane protein belonging to the ABC transporter family functioning as a chloride/anion channel in epithelial cells around the body. There are over 1500 mutations that have been characterised as CF-causing; the most common of these, accounting for ~70 % of CF cases, is the deletion of a phenylalanine at position 508. This leads to instability of the nascent protein and the modified structure is recognised and then degraded by the ER quality control mechanism. However, even pharmacologically 'rescued' F508del CFTR displays instability at the cell's surface, losing its channel function rapidly and it is rapidly removed from the plasma membrane for lysosomal degradation. This review will, therefore, explore the link between stability and structure/function relationships of membrane proteins and CFTR in particular and how approaches to study CFTR structure depend on its stability. We will also review the application of a fluorescence labelling method for the assessment of the thermostability and the tertiary structure of CFTR. |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 196 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 23% |
| Student > Master | 22 | 11% |
| Student > Ph. D. Student | 21 | 11% |
| Researcher | 15 | 8% |
| Student > Doctoral Student | 9 | 5% |
| Other | 18 | 9% |
| Unknown | 68 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 58 | 29% |
| Medicine and Dentistry | 21 | 11% |
| Agricultural and Biological Sciences | 16 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Computer Science | 3 | 2% |
| Other | 18 | 9% |
| Unknown | 70 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2023.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#80,240
of 322,265 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 51 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.