| Title |
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
|
|---|---|
| Published in |
Current Hypertension Reports, March 2017
|
| DOI | 10.1007/s11906-017-0725-2 |
| Pubmed ID | |
| Authors |
Nathan S. Bryan, Gena Tribble, Nikola Angelov |
| Abstract |
Having high blood pressure puts you at risk for heart disease and stroke, which are leading causes of death in the USA and worldwide. One out of every three Americans has hypertension, and it is estimated that despite aggressive treatment with medications, only about half of those medicated have managed blood pressure. Recent discoveries of the oral microbiome that reduces inorganic nitrate to nitrite and nitric oxide provide a new therapeutic target for the management of hypertension. The presence or absence of select and specific bacteria may determine steady-state blood pressure levels. Eradication of oral bacteria through antiseptic mouthwash or overuse of antibiotics causes blood pressure to increase. Allowing recolonization of nitrate- and nitrite-reducing bacteria can normalize blood pressure. This review will provide evidence of the link between oral microbiota and the production of nitric oxide and regulation of systemic blood pressure. Management of systemic hypertension through maintenance of the oral microbiome is a completely new paradigm in cardiovascular medicine. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 26% |
| Spain | 5 | 13% |
| Switzerland | 1 | 3% |
| Netherlands | 1 | 3% |
| Chile | 1 | 3% |
| Austria | 1 | 3% |
| New Zealand | 1 | 3% |
| Unknown | 19 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 77% |
| Scientists | 5 | 13% |
| Practitioners (doctors, other healthcare professionals) | 4 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 152 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 12% |
| Student > Ph. D. Student | 17 | 11% |
| Researcher | 17 | 11% |
| Student > Master | 17 | 11% |
| Other | 15 | 10% |
| Other | 29 | 19% |
| Unknown | 39 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 28% |
| Agricultural and Biological Sciences | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 13 | 8% |
| Immunology and Microbiology | 9 | 6% |
| Nursing and Health Professions | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 46 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2023.
All research outputs
#670,100
of 25,653,515 outputs
Outputs from Current Hypertension Reports
#24
of 789 outputs
Outputs of similar age
#13,696
of 323,672 outputs
Outputs of similar age from Current Hypertension Reports
#1
of 25 outputs
Altmetric has tracked 25,653,515 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 789 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.